Present report studies the hydro-geomorphology of the Seine estuary, and is the second report of Flanders Hydraulics Research within the ANPHYECO project. The hydro-geomorphological characterisation of the Seine is based on data analysis and follows the methodology as applied in the TIDE project (Vandenbruwaene et al., 2013). This enables the comparison of the Seine estuary with other European estuaries in terms of tidal amplification/damping and morphology, hydrodynamics and suspended particle matter, and residence times. The interestuarine comparison demonstrates that: (1) the low convergence of the Seine leads to tidal damping along the estuary despite the large estuary depth, (2) the SPM pattern in the estuary is to a great extent determined by the tide and the freshwater discharge regime, and (3) the residence time for the Seine estuary can be considered as low. With regard to the historical evolution of the Seine we observe an important deepening of the estuary between 1960 and present. Moreover, we observe a significant decrease in SPM over the period 1955-2013, in combination with an increase in the freshwater discharge.